In mammals, autophagy is an evolutionarily conserved process where cytoplasmic components are typically degraded within the lysosome. Consequently, the degraded cargo is recycled depending on the ...

Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional ...

The original definition of autophagy (Greek, “self-eating”) is the delivery of cytoplasmic cargoes to the lysosome for degradation. This process is conserved in all eukaryotic organisms, occurs at ...