Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since ...

(a) Design of a microfluidic chip included a top and a bottom channel separated by a central membrane (b) Induced pluripotent stem cell (iPSC)-derived cardiomyocytes and fibroblasts adhered to the top ...

Cardiotoxicity underlies a third of failures in regulatory clearance, making it among the most significant hurdles in developing new drugs. 1 axoCells human iPSC-derived ventricular cardiomyocytes ...

“For decades, researchers have been trying to find the specialized cells that make new muscle cells in the adult heart, and we think that we have found that cell,” Hesham Sadek, the senior author of ...

This diagram illustrates how the combination of fibroblast growth factor 4 and ascorbic acid activates the JAK2–STAT3 signaling pathway, promoting the maturation of induced cardiomyocytes (iCMs). This ...

The induction of the cell cycle in cardiomyocytes involves the activation of specific genes that are responsible for regulating cell division and growth. Our laboratory has discovered several ...

University of Alabama at Birmingham researchers, led by Jianyi “Jay” Zhang, M.D., Ph.D., and Lei Ye, M.D., Ph.D., generated the human leukocyte antigen-knockout ...

When we developed the ability to convert various cells into a stem cell, it held the promise of an entirely new type of therapy. Rather than getting the body to try to fix itself with its cells or ...

The problem is that mammalian heart muscle cells, known as cardiomyocytes, lose their ability to proliferate shortly after birth. Researchers have long sought to induce these cells to start dividing ...

Researchers have harnessed a combination of lab-grown cells to regenerate damaged heart muscle. The study addresses major challenges of using heart muscle cells, called cardiomyocytes, grown from stem ...