Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins. Now a ...

The effects of disease-associated genetic variants on gene expression and genome accessibility have been analysed together.

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor Hirohisa Ohno (Department of Life Science Frontiers at CiRA) recently led a ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, intriguingly, many of the most important proteins involved in gene ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Researchers say gene switches currently offer limited temporal and spatial precision and can also have adverse effects. Now, a recent study, “Electromagnetic field-inducible in vivo gene switch for ...

A comparative study of mouse germ cell promoters finds the Ldhc promoter drives the strongest and most reliable transgene ...

An international team of researchers has assembled one of the largest single-cell genetic atlases ever built, profiling more ...

Gene expression in eukaryotes is governed not only at the level of transcription but also by tightly regulated steps in the translation of mRNA into protein. Control mechanisms span initiation, ...

Genes make up the blueprints and outline the process of building every living organism. To ensure that the right genes are activated in the right cells, and in the right amounts at the right time, ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. Alternative splicing—the way cells edit gene messages—forms a second, independent layer of ...