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Hirschsprung disease, also known as congenital megacolon, aganglionic megacolon or primary megacolon, is a functional bowel obstruction that usually manifests in newborn babies. It occurs due to the ...

A manometric technic is described for the diagnosis of Hirschsprung's disease without the necessity of deep-muscle rectal biopsy. Separate pressure recordings were obtained from the internal and ...

Q: Which doctor treats Hirschsprung disease? A: Hirschsprung disease is treated by a pediatric surgeon or pediatric gastroenterologist. Q: Is Hirschsprung disease hereditary? A: Hirschsprung disease ...

Hirschsprung-associated enterocolitis (HAEC): causes and possible treatments HAEC is associated with significant mortality and morbidity, yet its pathogenesis remains unknown. Changes in the colonic ...

Defects in the protein Sox10, a transcription factor that regulates gene expression, may play a role in the development of post-operative GI dysfunction in Hirschsprung's disease patients, according ...

When doctors in China removed 30 inches of a young man's colon, they also removed nearly 29 lbs. (13 kilograms) of his feces. The 22-year-old's belly had swelled past the size that would be seen in a ...

Dr. Marc Levitt is Surgical Director for the Center for Colorectal and Pelvic Reconstruction at Nationwide Children's Hospital. He contributed this article to Live Science's Expert Voices: Op-Ed & ...

For many patients with Hirschsprung disease, the underlying pathogenic mechanisms are unknown. A new study using a novel line of transgenic mice and tissue from patients with Hirschsprung disease ...

Hirschsprung disease is a congenital disorder clinically characterized by the absence of colonic ganglia and genetically by extensive heterogeneity. Genes involved include RET, GDNF, EDNRB and EDN3.

When a newborn is unable to pass stool, the cause could be Hirschsprung’s Disease, a rare congenital disorder that can lead to serious complications. Dr. Michael Rollins explains the disease and how ...