The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.

The Major Histocompatibility Complex is a genetic region characterized by a high density of genes, many of them involved in the immune response. Of considerable importance are the HLA class I and ...

The result is one molecule that can be both a checkpoint degrader and a cancer vaccine ( Nature 2026, DOI: 10.1038/s41586-025 ...

This is a preview. Log in through your library . Abstract In many species, individuals prefer mates that are genetically dissimilar at the major histocompatibility complex (MHC), likely because it ...

The study, according to the researchers, is the first to demonstrate the potential use of major histocompatibility complex class II (MHC-II) expression as a predictor of immunotherapy response in ...

Proteins of the major histocompatibility complex (MHC) play a central role in the presentation of antigens to the adaptive immune system. The MHC also influences the odour-based choice of mates in ...

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...