Throughout our evaluation of mutation enrichment by COLD-PCR platforms, we have observed a trend for the mutation enrichment related to the initial abundance of the mutation or variant fraction. As ...

Background and Aim: Long-term lamivudine treatment for chronic hepatitis B virus (HBV) infection induces the emergence of lamivudine resistant HBV YMDD mutant strains. The aim of the present study was ...

Protein S-100β serum levels predicts clinical outcome of high-risk melanoma patients treated with high-dose adjuvant interferon alfa2b No significant financial relationships to disclose. This is an ...

Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study Plasma cfDNA and pathology specimens of 36 patients were analyzed. Agreement ...

Philadelphia, February 10, 2022 – Using a routine blood sample, investigators have developed an extremely sensitive assay to detect and quantify DNA fragments containing rare genetic mutations in a ...

Breast cancer patients with PI3KCA mutations are less likely to achieve a pathological complete response (pCR) from dual HER2 blockade in the neoadjuvant setting, according to an analysis of the ...

Higher Throughput and More Sensitive Techniques Keep Workhorse Tool at the Forefront After more than 25 years of use, PCR remains a workhorse in molecular biology. New applications, new reporter ...

The presence or absence of the PCR product is then recorded. The information will then be used to determine the genotype of each individual for VKORC1, with the possibility of being Homozygous Wild ...

Using a routine blood sample, investigators have developed an extremely sensitive assay to detect and quantify DNA fragments containing rare genetic mutations in a patient's cancer cells. This assay ...

Study Shows How Melting Point Analysis Infers the Presence of and Identifies SNPs The melting temperature (T m) of a PCR product is dependent on both the length and sequence of the DNA. Melting curve ...