Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid and glucose metabolism and cellular differentiation. PPAR-α and PPAR-γ are both expressed in human ...

Diet is among the most important factors contributing to intestinal homeostasis, and basic functions performed by the small intestine need to be tightly preserved to maintain health. Little is known ...

The metabolic syndrome is by now unequivocally established in the minds of endocrinologists as a common and burgeoning disease linked to premature atherosclerosis and cardiovascular disease. Many ...

Chronic myeloid leukemia (CML) is a myeloproliferative disease that occurs because of a translocation between chromosomes 9 and 22 in hematopoietic stem cells. The switch results in a fusion of the ...

Researchers are exploring a novel quintuple agonist that targets five pathways, including GLP-1R, GIPR, and three PPARs. This innovative approach combines the benefits of incretin and PPAR pathways, ...

In a study that could lead to new therapeutic targets for patients with the cystic fibrosis, scientists have identified a defective signaling pathway that contributes to disease severity. In a study ...

Much excitement has built in recent years on the new class of incretin drugs that include glucagon-like-peptide-1 inhibitor (single agonists such as semaglutide) and also dual glucose-dependent ...

According to the researchers, their finding will offer important insights into the machinery that powers muscle development and the physiological changes produced by exercise. The finding also ...

(Feb. 15, 2010) - In a study that could lead to new therapeutic targets for patients with the cystic fibrosis, a research team from the University of California, San Diego School of Medicine has ...

In recent years, a new class of incretin drugs that includes glucagon-like-peptide-1 inhibitors (single agonists such as semaglutide) and also dual glucose-dependent insulinotropic polypeptide (GIP) ...