High background noise in RNA samples can impact read accuracy and increase sequencing costs. Optimizing sample quality enables better microRNA mapping and more reliable insights in transcriptomics and ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

Our results demonstrate that differential connectivity analysis reveals significant transcriptional alterations that are not ...

Years of experiments and databases filled with RNA-seq results belie the simple reality that, until fairly recently, it was impossible to analyze RNA directly. The RNA-seq studies performed with ...

Human disease is complex and influenced by a wide range of genomic variants. Sequencing accuracy is paramount in order to detect this vast array of genomic dysfunction. In genomic and multiomic ...

A research team led by Prof. TAN Weihong and Prof. WU Qin from the Hangzhou Institute of Medicine (HIM) of the Chinese Academy of Sciences has developed a pioneering, multi-modal platform called SPARK ...

Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...