New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
EurekAlert!

Researchers uncover how tumors become resistant to promising p53-targeted therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

Scientists identify pre-cancerous states in seemingly normal aging tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
STAT

NIH cuts will set back research into the rare disease that has terrorized my family

Higgins is an advocate for people with Li-Fraumeni syndrome. I was born with an inherited cancer syndrome, Li-Fraumeni syndrome (LFS). A mutation on my Tp53 cancer suppressor gene makes me susceptible ...
Hosted on MSN

Sperm donor's rare cancer gene puts 200 children at risk

* One sperm donor was linked to nearly 200 births across multiple countries * Several children inherited a high-risk TP53 cancer mutation * Case exposes gaps in genetic screening //and donor ...
The American Journal of Managed Care

Genomic Profiling in Colorectal Cancer Reveals Prognostic Markers

CGP identifies TP53 and SMAD4 mutations as negative prognostic markers, while PTEN mutations correlate with improved survival in CRC patients. Despite no significant survival advantage, CGP-guided ...
The Conversation

Genetic tests for cancer can give uncertain results: new science is making the picture clearer to guide treatment

Claudia Christowitz received funding from the National Research Foundation, South Africa. Cancer treatment is becoming more personalised. By considering a patient’s unique genetic and molecular ...